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Histamine-A decarboxylation product of the amino acid histadine. Histamine is found in all body tissues, especially the mast cells and basophils, the highest concentration being in the lungs. The functions of histidine include 1) dilation of capillaries, which increase the permeability of the capillary and result in a reduction in blood pressure, 2) causing smooth muscle to contract, including the bronchial smooth muscle of the lungs. This is observed in allergic reactions and asthmatic attacks, 3) Stimulation of gastric secretions 4) increases in heart rate and 5) possible neurotransmission.